Synthesis of Well - Defined Amphiphilic Diblock Copolymers Having Biocompatible Phospholipid Polymer
نویسندگان
چکیده
Combinations of lecithin with hydrophilic (e.g. C8-PEG) and lipophilic (e.g. sorbitan monooleate) linkers (unbalanced amphiphiles) have been used to produce microemulsions with a wide range of oils. The resulting microemulsions have been found to be biocompatible through a number of tests, including cell viability tests, Human Repeat Insult Patch Test (HRIPT), and Ames test. In this presentation we will discuss the in-vitro and in-vivo performance of an antiwrinkle formula developed using linker-based microemulsions, and the importance of controlling the viscosity of microemulsion-based products for topical applications.
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